Figure 3.
Lineage analyses of output from edited HSPC.TET2 target site indel frequencies were analyzed in lineages of blood cells purified from ZL26, ZL39, and ZH63. (A) Indel frequencies in myeloid lineages, including macrophages (CD14+CD163+), classical monocytes (CD14+CD16−) and granulocytes (top), and lymphoid lineages, including helper T cells (CD4+), cytotoxic T cells (CD8+), B cells (CD20+), and mature (CD16+NKG2A+) and immature (CD56+) NK cells (bottom). (B) All indel types at the TET2 target site identified in any lineages from the 3 animals are listed on the bottom with unique colors. Indels are highlighted in red font, and the PAM sequence is underlined. The percent contribution of each indel in each cell type over time is shown in the graphs at the top.

Lineage analyses of output from edited HSPC.TET2 target site indel frequencies were analyzed in lineages of blood cells purified from ZL26, ZL39, and ZH63. (A) Indel frequencies in myeloid lineages, including macrophages (CD14+CD163+), classical monocytes (CD14+CD16−) and granulocytes (top), and lymphoid lineages, including helper T cells (CD4+), cytotoxic T cells (CD8+), B cells (CD20+), and mature (CD16+NKG2A+) and immature (CD56+) NK cells (bottom). (B) All indel types at the TET2 target site identified in any lineages from the 3 animals are listed on the bottom with unique colors. Indels are highlighted in red font, and the PAM sequence is underlined. The percent contribution of each indel in each cell type over time is shown in the graphs at the top.

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