Patient cohort composition and observed cytogenetic and molecular landscapes of Black and White AYA patients with AML. (A) A consort diagram of AYA patients with AML aged 18 to 39 years who were treated on the CALGB/Alliance study protocols. APL, acute promyelocytic leukemia. (B) The frequency distribution of cytogenetic findings in Black compared with that in White patients. (C) Bar graphs showing frequencies of pathogenic variants in known AML-associated genes detected in Black and White patients with AML, sorted by descending frequencies of variants found in Black patients. Depicted are only genes that were found mutated in ≥3% of patients.