Molecular composition and clonal evolution of select Black AYA patients with AML at the time of AML diagnosis and at relapse. (A) Fish plots depicting clonal changes in pathogenic variants of AML-associated and less well-known genes between diagnosis and relapse, as identified by whole-exome sequencing of samples from 4 Black patients with AML. (B) Copy number changes detected at diagnosis and relapse in the same 4 Black patients with AML.