Expanded unique T-cell clones originate in the TEMRA compartment. (A) C_MH, ranging from 0 (the samples are entirely different) to 1 (the samples are identical), shows the overlap between clones detected in the overall T cells and clones detected in the TEMRA cells from the same patients. The mean C_MH value of the TCR repertoires was >0.4 between T-cell and TEMRA cell compartments. In comparison, there was no overlap between patients. (B) Percentage space occupied by the largest clonotype among T-cell and TEMRA compartment in 3 patients with ITP. (C) 3D-plot visualization of the composite TRBV and TRBJ repertoire of the TEMRA compartment compared with non-TEMRA CD8⁺ T cells and CD4⁺ cells combined.