Figure 5.
Inhibition of PAR1-mediated Gαq signaling reduces doxorubicin-induced cardiac injury. LV FS was assessed on day 5 in Par1+/+ mice and Par1R41Q mice treated with Q94 or Veh in an acute model of doxorubicin-induced cardiac injury by conscious echocardiography (n = 5-8/group). ∗P < .05; ∗∗P < .01; ∗∗∗P < .005; 2-way ANOVA with post hoc Holm-Sidak tests. Data are represented as individual values with mean and SEM. Veh, vehicle control.

Inhibition of PAR1-mediated Gαq signaling reduces doxorubicin-induced cardiac injury. LV FS was assessed on day 5 in Par1+/+ mice and Par1R41Q mice treated with Q94 or Veh in an acute model of doxorubicin-induced cardiac injury by conscious echocardiography (n = 5-8/group). ∗P < .05; ∗∗P < .01; ∗∗∗P < .005; 2-way ANOVA with post hoc Holm-Sidak tests. Data are represented as individual values with mean and SEM. Veh, vehicle control.

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