Antispike mediated T-cell response in patients with CLL. (A) Seroconversion rate. (B) T-cell response rate after 2-dose and 3-dose vaccines in patient subgroups based on clinical parameters and treatment status. Y-axis presents the proportions (%) of patients with CLL. S, standard of active level, IgG, 552 mg/dL; IgM, 33 mg/dL; and IgA, 69 mg/dL. Cutoff value for lack of antibody seroconversion (standard of active level) was set as <0.8. Cutoff value for a detectable IFN-γ response was >0.1 IU/mL.