Immune transcriptomes following vaccination. (A-C) Interferon-regulated genes are induced upon vaccination. Genes expressed at significantly higher levels at days 2 and 7 compared with those at day 0 were significantly enriched in Hallmark gene sets. X-axis denotes statistical significance as measured by minus logarithm of FDR q-values. Y-axis denotes ranked terms by q-values. (D) Heatmaps show log2 FC of IFN-γ response genes (top) and G2M target genes (bottom) significantly regulated between day 0 and day 2, day 2 and day 7, and day 0 and day 7. FDR, false discovery rate; G2M, G2/M checkpoint.