Comparison of immune transcriptomes by vaccine doses as well as antibody response after vaccination. (A) Genes expressed at significantly higher levels between days of 2-dose and 3-dose groups were significantly enriched in Hallmark gene sets. X-axis denotes statistical significance as measured by minus logarithm of FDR q-values. Y-axis ranked the terms by q values. (B) Heatmaps showing log2 FC of significantly upregulated genes between day 0 and day 1 of 2-dose and 3-dose groups. (C) Hallmark gene sets of genes expressed at significantly higher levels between days of nonresponder and responder groups. (D) Heatmaps of genes significantly activated between day 0 and day 1 of 2-dose and 3-dose groups. FDR, false discovery rate.