Prognostic value of LSC burden at diagnosis. (A) Kaplan-Meier curve for OS. (C) CIR. The overall group (A,C) is divided into CD34^neg, LSC^low, and LSC^high, with the cut-off of 0.03% CD34⁺CD38^–LSC⁺ population of WBCs. (B,D) Multivariate analysis adjusted for age, AML type, ELN2017 risk group, WBCs at diagnosis, and last treatment before reaching CR (only for CIR) of (B) OS (Cox regression) and (D) CIR (Fine and Gray regression).