Immune phenotype by mass cytometry. (A) Uniform manifold approximation and projection (UMAP) of immune cell subset clusters analyzed by mass cytometry on whole blood samples from DOCK11 patients (n = 7) and age-matched HDs (n = 6). Each cluster is color coded. (B) Cell cluster biases observed between DOCK11 patients and HDs. DOCK11 patients have a significantly lower percentage of CD56_bright natural killer (NK) cells, late NK cells, MAIT cells, and memory B cells. Two-tailed P values were determined with a nonparametric Mann-Whitney test. ∗P < .05; ∗∗P < .01; ∗∗∗P < .005.