Figure 3.
Immunologic impact of LD IL-2 on lymphocytes. (A) Absolute Treg count for all dose levels combined. Box plots depict the 75th percentile, median, and 25th percentile values; whiskers represent maximum and minimum values, except for outliers (>1.5 times the interquartile range above Q3 or below Q1). (B) Treg:Tcon ratio for dose level C patients receiving Treg DLI plus LD IL-2 (red) compared with a historical control group receiving LD IL-2 alone (blue). (C) Absolute CD8+ T-cell (red), NK-cell (blue), and CD4+ Tcon (green) counts are shown for dose level C patients. Median values (dots) and the interquartile range (whisker bars) are shown at each time point. The number of patients evaluated at each time point is indicated at the bottom of each graph.

Immunologic impact of LD IL-2 on lymphocytes. (A) Absolute Treg count for all dose levels combined. Box plots depict the 75th percentile, median, and 25th percentile values; whiskers represent maximum and minimum values, except for outliers (>1.5 times the interquartile range above Q3 or below Q1). (B) Treg:Tcon ratio for dose level C patients receiving Treg DLI plus LD IL-2 (red) compared with a historical control group receiving LD IL-2 alone (blue). (C) Absolute CD8+ T-cell (red), NK-cell (blue), and CD4+ Tcon (green) counts are shown for dose level C patients. Median values (dots) and the interquartile range (whisker bars) are shown at each time point. The number of patients evaluated at each time point is indicated at the bottom of each graph.

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