Detection capacity of genomic aberrations with different technologies.¹Includes various technologies that may interrogate single nucleotide changes through to the sequence of the entire gene (AS-PCR, fragment analysis, Sanger sequencing, and others). ²Includes gene expression arrays, NanoString, and RT-MLPA assays. ³Most technologies, except FISH, cannot detect subclonal CNAs (<20%) with high confidence. ⁴Including gene fusions. Ticks indicate good capacity to determine a certain aberration/feature, whereas an inverted red triangle indicates a limited/insufficient detection capacity. AS-PCR, allele-specific oligonucleotide polymerase chain reaction; CNA, copy number aberration; IG, immunoglobulin; indel, insertion-deletion; RT-MLPA, reverse transcriptase multiplex ligation–dependent probe amplification; TR, T-cell receptor locus. Created with BioRender.com.