Genetic subgroups of DLBCL illustrated using the LymphGen algorithm. The relationships between COO and the probabilistic assignments to genetics-based subgroups are shown. The size of the subgroup circles approximates the proportions of patients in each group, with the prevalence based on Schmitz et al,185 adjusted for a population-based distribution of COO subgroups. Tumors assigned with high confidence to ≥2 subgroups are assigned to the composite group, while ∼37% of tumors are not assigned to any subgroup with sufficient confidence (other). The hallmark genetic features are those frequent within that subgroup but are not required for that assignment. OS following R-CHOP chemoimmunotherapy along with inferred drug targets are shown. GCB, germinal center B-cell–like.
