Mnk1 regulates thrombus formation in vitro and in vivo. (A-D) WT (n = 8) or Mnk1 KO (n = 9) mice were subject to a venous stasis model of thrombosis. (A) Representative clots from WT or Mnk1 KO mice. (B) Number of mice in each group with thrombosis (∗P < .05). (C-D) Clots were removed, measured, and weighed (∗P < .05). (E) Survival proportions in WT and Mnk1 KO mice after induction of pulmonary thromboembolism by injecting a collagen/epinephrine mixture through retro-orbital injection (n = 10 mice per group, ∗P < .05).