Genomic characterization of PDGFR rearrangements. (A) Absolute eosinophil count before (tumor) and after treatment (normal) with imatinib. (B) GISTIC2 plot depicting the significantly recurrent interstitial deletion on chromosome 4. (C) Genomic view of the F/P locus showing detected deletions (blue bars) in most samples. (D) Detailed view of the breakpoints inside the FIP1L1 gene. Colored lines show location inside introns labeled with matching intron numbers (based on transcript NM_001134937.1). (E) Circos plot¹¹ of the complex PDGFRB rearrangement in patient HES11. Purple lines indicate genomic fusions between the chromosomal regions. (F) Gene locus and inferred protein fusion between PDGFRB and IQGAP2.