Tumor-expressed FVII expression is positively associated with breast tumor progression. (A) Representative image of a tissue microarray staining for FVII protein expression in a cohort of 574 breast tumors. (B) FVII mRNA expression was verified in 20 FVII⁻ and 20 FVII⁺ tumor specimens. FVII expression is associated with grade (C) and T-status (D). (E) Metastasis-free survival in patients younger and older than 55 years. (F) Overall survival in patients younger and older than 55 years. (G) Association between FVII expression and the first-diagnosed site of metastasis.