CD127 expression and IL7Rp mutational status define 3 categories of T-ALL. (A) sIL-7R expression level (percentage of CD127⁺ blasts) for each T-ALL from the adult cohort (n = 200) classified based on the combination of sIL-7R status (positive if ≥20% blast cells) and IL7R/JAK1/JAK3/STAT5B mutational status in 3 categories (gray, T-ALL^IL-7R–/low or nonexpressers; blue, T-ALL^IL-7R+/WT or expressers; red, T-ALL^Mut or mutants). (B) (Left) Bar chart depicts the relative proportions of the 3 T-ALL categories in each immunophenotypic subgroup (n = 198). χ²test. ∗∗∗∗P < .0001. (Right) Pie charts depict the relative proportions of the different immunophenotypic subgroups for the 3 T-ALL categories. (C) (Left) Bar chart depicts the relative proportions of the 3 T-ALL categories in each oncogenetic subgroup (n = 190). χ² test. ∗∗∗∗P < .0001. (Right) Pie charts depict the relative proportions of the different oncogenetic subgroups for the 3 T-ALL categories. None: overexpression of HOXA9, TLX1, TLX3, or SIL-TAL microdeletion were not found.