C1-INH antigen and activity levels increase upon Cinryze administration. Both C1-INH antigen (A) and activity (B) levels increase upon administration of four C1-INH doses in the first 36 h, reaching maximum levels at 48 h after first administration respectively. Red area indicates normal healthy levels of C1-INH antigen and activity. Data expressed as median + IQR, significance tested using Wilcoxon matched-pairs signed rank test. ∗P ≤ 0.05.