Different evolution patterns in SMZL-T. Total number of shared and unique alterations identified in patients with paired diagnostic/transformed samples. (A) Bar plot showing the overall shared aberrations in each case between diagnosis and transformed samples. (B) Unique genomic aberrations identified in each case, at diagnosis (left) and at transformation (right). SNVs, indels, gains, losses, and CN-LOH were considered. The asterisks indicate the cases with no CN array data. Models of divergent (C) and linear (D) evolution patterns during SMZL transformation. Upper panels: simplified models; lower panels: an example of each type, case SMZL059 as an example for divergent evolution (C) and case SMZL045, the only case with linear evolution (D). Green and pink cell aggregates depict the SMZL and SMZL-T clones, respectively, common mutated precursor cell (CPC) in orange, and normal B cell is represented in blue.