Survival from time of transformation. (A) Impact of genetic alterations or (B) the cumulative number of (N.) of genetic changes present at transformation on SFT. The impact is quantified with the hazard ratio and its 95% confidence interval. Continuous variables were scaled. The gray, red, blue, and yellow boxes indicate the type of genetic alterations found in each alteration (SNVs/indel, loss, gain, and CN-LOH, respectively). The right columns show: the number of cases (n) and events (evt.), the number of altered cases (no. alt.), and the P value (P-val) of the log-rank test (for dichotomous variables) or of the Cox regression (for continuous variables). Only alterations with at least 4 altered cases at transformation are shown. Complex karyotype (CK) is dichotomized and defined by the presence of 3 or more aberrations. (C-D) Kaplan-Meier curves of SFT based on (C) the presence of KLF2 mutations or (D) complex karyotype at transformation.