Figure 4.
IgG autoantibody antigen specificity did not relate to the magnitude of macrophage phagocytosis of platelets mediated by patient serum. All patients with ITP negative for MHC class I alloantibodies (19 total patients) were included in the analysis. The median of each grouping is shown as a horizontal line. The NHS mean ± 2 SD cutoff is depicted by the gray-shaded area. (A) ITP sera were grouped according to the presence or absence of detectable autoantibodies against GPIIb/IIIa, GPIb/IX, or GPIa/IIa. Each dot indicates the mean phagocytic index obtained for an individual ITP serum. ∗P ≤ .05, by 2-tailed Welch’s unequal variances t test. Data was determined to have a normal (Gaussian) distribution by the Shapiro-Wilk test. (B) ITP sera were grouped by the number of antigens targeted by autoantibodies. (C) ITP sera were grouped according to their particular autoantibody profiles.

IgG autoantibody antigen specificity did not relate to the magnitude of macrophage phagocytosis of platelets mediated by patient serum. All patients with ITP negative for MHC class I alloantibodies (19 total patients) were included in the analysis. The median of each grouping is shown as a horizontal line. The NHS mean ± 2 SD cutoff is depicted by the gray-shaded area. (A) ITP sera were grouped according to the presence or absence of detectable autoantibodies against GPIIb/IIIa, GPIb/IX, or GPIa/IIa. Each dot indicates the mean phagocytic index obtained for an individual ITP serum. ∗P ≤ .05, by 2-tailed Welch’s unequal variances t test. Data was determined to have a normal (Gaussian) distribution by the Shapiro-Wilk test. (B) ITP sera were grouped by the number of antigens targeted by autoantibodies. (C) ITP sera were grouped according to their particular autoantibody profiles.

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