Figure 5.
EHBP1L1-deficient erythrocytes are prone to hemolysis. (A) The percentage of hemolysis in enucleated erythrocytes isolated from the peripheral blood of control and Ehbp1l1−/− E18.5 embryos when exposed to the indicated hypotonic solutions is shown (n = 4). The data are representative of 3 independent experiments. (B) A representative picture of serum from control and Ehbp1l1−/− E18.5 embryos is shown. (C) The bilirubin concentration in serum from control (n = 19) and Ehbp1l1−/− (n = 6) E18.5 embryos and P0 mice was determined by using the UnaG protein. (D) Representative images of Berlin blue staining of liver tissues are shown. The areas enclosed in the black squares were enlarged. Scale bars: 10 μm. The data are presented as means ± SEMs for panels A,C. ∗P < .05, ∗∗P < .01 (unpaired t test with Welch’s correction).

EHBP1L1-deficient erythrocytes are prone to hemolysis. (A) The percentage of hemolysis in enucleated erythrocytes isolated from the peripheral blood of control and Ehbp1l1−/− E18.5 embryos when exposed to the indicated hypotonic solutions is shown (n = 4). The data are representative of 3 independent experiments. (B) A representative picture of serum from control and Ehbp1l1−/− E18.5 embryos is shown. (C) The bilirubin concentration in serum from control (n = 19) and Ehbp1l1−/− (n = 6) E18.5 embryos and P0 mice was determined by using the UnaG protein. (D) Representative images of Berlin blue staining of liver tissues are shown. The areas enclosed in the black squares were enlarged. Scale bars: 10 μm. The data are presented as means ± SEMs for panels A,C. ∗P < .05, ∗∗P < .01 (unpaired t test with Welch’s correction).

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