Association between ABCB1 or VEGF-A–grouped genotypes and survival in a randomly assigned population. PFS stratified based on ABCB1 genotypes in the LEN (A) and OBS arms (C); OS stratified based on ABCB1 genotypes in the LEN (B) and OBS arms (D); PFS stratified based on VEGF-A genotypes in the LEN (E) and OBS arms (G); OS stratified based on VEGF-A genotypes in the LEN (F) and OBS arms (H). ABCB1: HoWT = GG, HePOL = GW, HoPOL = WW; VEGF-A: HoWT = AA, HePOL = AC, HoPOL = CC.