ANKL-PDXs reproduce human clinical features. (A) Hematoxylin and eosin (H&E) staining (left: low-power field; upper-right: high-power field) and EBV-encoded RNA in situ hybridization (EBER-ISH) (lower-right) of the liver, BM, and spleen sections derived from an ANKL1 PDX mouse. Representative image from 3 independent experiments. Scale bar, 200 μm (low-power field) and 20 μm (high-power field). (B) Bioluminescent signal detected using the IVIS in ANKL1 PDX mice (n = 3). The upper and lower panels show the supine and prone positions, respectively.