In the clinical PET (cPET) radiomics model, the combination of metabolic tumor volume (MTV), peak standardized uptake value (SUV_peak), maximum distance between the largest lesion and its most distant lesion (Dmax_bulk), patient age, and performance status (PS) outperformed the standard International Prognostic Index (IPI) in identifying the group of patients with diffuse large B-cell lymphoma (DLBCL) with the most unfavorable prognosis. SDmax, maximum standard deviation. The left side of the figure is adapted from an image supplied by M. Meignan with permission. The right side is modified from Figure 3 in the article by Eertink et al that begins on page 3055. Professional illustration by Patrick Lane, ScEYEnce Studios.