Epcoritamab-induced cytotoxicity in CLL PBMCs correlates with the E:T ratio but not with CD20 expression levels. (A) Comparison of baseline E:T ratio, calculated as follows: (% CD4⁺ and CD8⁺ T cells) ÷ % CLL cells, in indicated patient groups: TN (n = 13, red triangles), IBR (n = 12, blue circles), ACA (n = 14, green diamonds), and RES (n = 7). (B) Spearman correlation of baseline E:T ratios and percentage of CLL cell–specific lysis in samples from all 4 groups cultured with epcoritamab for 7 days. (C) Comparison of baseline CD20 mean fluorescence intensity (MFI) in CLL cells between different patient groups. (D) Spearman’s correlation of baseline CD20 MFI and percentage of specific lysis of CLL cells in samples from all 4 groups cultured with epcoritamab for 7 days. Asterisks indicate statistical significance using Mann-Whitney test for the comparison of different patient groups. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001.