Comparisons of chromatin accessibility patterns from a data set of normal hematopoiesis with patients in this study. (A) Heatmap showing Pearson correlation values between pretreatment leukemias and 13 subtypes of cells from different stages of normal hematopoietic development. (B) Phylogenetic tree based on Pearson correlation between leukemias and subtypes of normal hematopoiesis from 3 separate healthy human donors. (C) Comparisons between PNR and PS stratified by similarity with healthy cells of hematopoietic development by Pearson correlation show that PNR (coral) are more similar to hematopoietic progenitors than PS (blue). There is no difference between the groups’ similarities to B cells or CLPs. Statistical significance was determined by Kolmogorov-Smirnov tests, and significance (P ≤ .05) is noted (∗). CMP, common myeloid progenitor; CLPs, common lymphoid progenitors; GMP, granulocyte-macrophage progenitor; HSC, hematopoietic stem cell; LMPP, lymphoid-primed multipotent progenitor; MPP, multipotent progenitor; MEP, megakaryocyte-erythroid progenitor; NK-cell, natural killer cell.