Gene modules 3 and 7 play a role in myeloma cell migration and viability. (A) z scores of 10 gene modules highly expressed in PCs from the BM and extramedullary sites. (B) Scores for gene signatures 3 and 7 in MPC clusters. (C) Pathways significantly enriched in EMICs. The cut-off criterion was a false-discovery rate <0.01. (D) Overall survival of patients with different expression of gene sets 3 and 7. Statistical significance was calculated using the log-rank test.