Effect of RN-1, decitabine, and the RN-1/decitabine combination. (A) F-retics and (B) γ-globin mRNA. Untreated: unfilled bars; RN-1:diagonal bars, decitabine: filled bars, Combination: horizontal bars. Interaction (left) and additivity (right) plots showing the synergistic effect of RN-1 and decitabine in combination on (C) F-retics and (D) γ-globin mRNA.