Integration of RadSig and MTV refines risk stratification in DLBCL. (A) PFS of the whole cohort of 112 patients according to the combination of MTV and RadSig status (integrated RadSig-MTV model). P value was calculated with the log-rank test. (B) OS in the whole cohort (112 patients) according to the integrated RadSig-MTV model. (C,D) Forest plots depicting multivariable analyses confirming a significant independent association with PFS and OS of the integrated RadSig-MTV model in the whole cohort after controlling for the IPI.