Identified BRAF and MEK1 alterations. Schematic representations of BRAF (A) and MEK1 (B) proteins with alterations detected in patients from our cohort. MEK1 is encoded by the gene MAP2K1. Figures not entirely to scale. AS, activation segment; ATP, adenosine triphosphate binding site; C, C-terminus; CL, catalytic loop; CR, conserved region; D, docking; del, deletion; DFG, DFG motif; ins, insertion; N, N-terminus; NES, nuclear export signal; NRR, negative regulatory region; P, phosphate-binding; Pro, proline.