IR at 30 minutes post–N8-GP dose in pathfinder6. (A) IR of all patients in pathfinder6. (B) Mean IRs of patients with temporarily decreased IR and all other non-inhibitor patients. IR at 30 minutes postdose was determined by chromogenic assay using a product-specific standard as calibrator. The EDs are approximated based on visit windowing and standard prophylaxis regimen. Temporarily decreased IR was defined as patients with an observation of 2 consecutive measurements of IR <0.6 (IU/dL)/(IU/kg) without inhibitor EDs.