IR of patients with temporarily decreased IR at 30 minutes vs antibody titer in pathfinder6. IR vs N8-GP binding (A), IR vs anti-PEG IgM (B), and IR vs anti-PEG IgG (C) antibody titers. IR at 30 minutes was determined by chromogenic assay using a product-specific standard as calibrator. Temporarily decreased IR was defined as patients with an observation of 2 consecutive measurements of IR <0.6 (IU/dL)/(IU/kg) without inhibitors.