Evolution of mHLA-DR values before and after anti-CD19 CAR T-cell infusion. (A) Individual patient time course showing the evolution of mHLA-DR levels during the first month after infusion. The bold trend curve is the cubic spline representation. (B) Violin plot showing the distribution of mHLA-DR at each time point for 1-year after infusion. The Wilcoxon matched-pairs test was used to calculate P values. The gray band delimits the 5th and 95th percentiles of normal values (ie, 13 500 and 35 200 Ab/c).