Figure 7.
Cell-mediated rescuing of HA phenotype in ZF model. (A) Clot formation times in laser-injured ZF (injuries are performed in duplicate and consequently in 2 sites of the CVP region) injected with human CD34+ cells and injured at day 1 (left) and day 2 (right) after injection (n ≥ 10, mean). (B) Clot formation time in laser-injured ZF injected with UM171-treated (red dots) and untreated (blue dots) sorted human CD34+ cells at days 1 and 3 after injection (n ≥ 7, mean). (C) Clot formation time in laser-injured HA ZF treated with 1.00 mM f8-MO only (gray dots) and injected with either sorted UT CD14+/CD31+ cells (blue dots) or sorted cells transduced with LV-hPGK-hBDDFVIII (red dots). Both UT and transduced cells were treated with UM171. Measurements were acquired on days 1 and 6 after injection (n ≥ 5, mean).