SCE5-scuPA, administered before photothrombotic stroke, improves the neurologic deficit after stroke. (A and B) Neurologic deficit scores at 1 and 3 days post-photothrombotic stroke, respectively. Median ± interquartile range. δP < .05, δδP < .01, δδδP < .001, δδδδP < .0001 compared with SCE5-scuPA by a Kruskal-Wallis test with uncorrected Dunn’s post hoc analysis. ∗∗P < .01 by a Mann-Whitney test (unpaired, 2-tailed). (C and D) Total cumulative foot slip time (C) and total foot slips per meter traveled (D). Mean ± standard error of the mean. #P < .05, ##P < .01 by 2-way analysis of variance with Tukey’s post hoc analysis. δP < .05, δδP < .01 by a paired t test (2-tailed). ∗P < .05, ∗∗P < .01 by an unpaired t test (2-tailed). n = 5-11.