Clonal and subclonal contribution of SBS signatures in WM. 96-class profile of genome-wide SBS mutations at the (A) clonal and (B) subclonal level. (C) SBS mutational signatures obtained after collapsing all genome-wide mutations at the clonal and subclonal level. (D-E) 96-class profile of SBS mutations specific to the immunoglobulin loci at the (D) clonal and (E) subclonal level. (F) SBS mutational signatures obtained after collapsing all mutations within immunoglobulin loci at the clonal and subclonal level.