Correlation of age of disease presentation with affected gene. Molteni et al describe deleterious germ line variants causing cytopenias and hypocellular bone marrows that vary across the age spectrum, with alleles in GATA2 and Fanconi anemia genes common in younger individuals and DDX41 in older individuals. Genes in which these alleles were identified are plotted as a function of age of presentation (on the x-axis) vs the diagnosis of the individual (top, ICUS/CCUS; bottom, myeloid malignancies; on the y-axis). Professional illustration by Somersault18:24.