Ex vivo cytotoxicity of SJ6986 and CC-90009 in PDX models of Ph-like ALLs. (A-C) SJ6986 and CC-90009 showed similar potency in PDX models of ALL harboring P2RY8-CRLF2 fusion and JAK2-R683G mutation (A), ATF7IP-Jak2 fusion (B), and EPORr with PAX5-P80R mutation (C). (D-F) SJ6986 showed less potency in 3 CRLF2r PDX models with P2RY8-CRLF2 fusion (D), P2RY8-CRLF2 and PAX5-ZNF521 fusions (E), and IGH-CRLF2 fusion with KRAS-G12D mutation (F).