Low USP9X expression is associated with poor survival in patients with high-risk B-ALL. (A) Kaplan-Meier curves are shown for overall survival in patients with high-risk B-ALL (n = 142; TARGET phase 2) expressing low (lowest quartile (in purple [n = 36]), intermediate (two middle quartiles in green [n = 70]), or high (highest quartile in yellow [n = 36]) levels of USP9X. (B) Kaplan-Meier curves are shown for event-free survival in patients with high-risk B-ALL (n = 207; TARGET ALL pilot project) from OncoGenomics DB comparing the lower quartile (in purple) versus the top three quartiles (in blue). For statistical analysis refer to the “Methods.”