DLBCLs with a Mac-enriched TIME have genetic signatures associated with immune evasion. Single nucleotide variants, structural variants, and copy number alterations in the indicated cases colored based on the aggregate TIME and arranged by genetic cluster designation as determined in the study by Chapuy et al.² Note that cases with an immune-deficient or a DC-enriched TIME are seen across cluster designations, whereas cases with a Mac-enriched TIME have signatures found in tumors associated with immune evasion (ie, clusters C1 and C5 and cluster C4 associated with a FAS mutation).