Immune cell responses to LD IL-2 therapy. Absolute cell counts for lymphocyte subsets including CD4⁺ Tregs, CD4⁺ Tcons, CD8⁺ T cells, NK cells, and B cells as well as Treg:Tcon ratio are shown at baseline and after 8 to 12 weeks of LD IL-2 therapy. If patients had both week 8 (W8) and week 12 (W12) values, these were averaged. Baseline refers to the value at the measurement directly before LD IL-2 was initiated. ∗P < .05, ∗∗P < .01, ∗∗∗P < .001.