Figure 3.
Genomic features and clonal dynamics in MRD-positive patients before alloHCT. (A) Leukemia-specific mutations found before alloHCT are grouped based on the function of the corresponding gene. The columns represent individual patients. They are grouped based on the clearance of MRD by D90. The red highlight marks 2 patients who were MRD positive who relapsed before D90. (B) Clonal dynamics in patients who did not clear MRD by D90. Clones harboring mutations in gray were not detected on D90 (D0+D90–). The graph with red highlights represents patients who relapsed by D90. VAF is presented on a logarithmic scale.