Mutational landscape of TP53-mutated myeloid malignancies.TP53-mutated AML (left) and MDS (middle), compared with AML driven by the CBFB::MYH11 or RUNX1::RUNX1T1 fusion proteins. Top: SNV/indel counts for each sample. Left: frequency of selected genomic alterations in TP53 samples. Middle: colors represent the types of mutations observed in each sample; asterisks indicate multiple SNV/indel hits. Bottom: proportion of each single-nucleotide base change per sample.