CD37 mediates both prosurvival and prodeath effects from its N- and C-termini. CD37 initiates cell death via phosphorylation of an immune tyrosine-based inhibitory motif (ITIM)-like motif in its N-terminus tail. This leads to a SHP1-dependent cell death. IT can also initiate prosurvival signaling through phosphorylation of its immune tyrosine-based activation motif (ITAM) on the C-terminus tail. This occurs through PI3K/Akt signaling.