sE-selectin overall population. sE-selectin levels (ng/mL) are shown before 40 mg/kg loading dose (T₀), 10 minutes postloading dose, 3 hours and 8 hours postloading dose, before first 20 mg/kg maintenance dose, 1 hour and 3 hours after first maintenance dose, before second 20 mg/kg maintenance dose, and 1 hour and 3 hours after second maintenance dose. All values are normalized to baseline sE-selectin value and plotted as percent of baseline value.