Overview of different strategies to administer DLI. (1) Prophylactic DLI is administered after a defined interval posttransplant to reduce the risk of relapse. (2) Preemptive DLI serves to restore GvL on impending relapse as detected by persisting MRD or LOC. (3) Therapeutic DLI is administered to treat overt hematologic relapse. Abbreviations: DLI, donor lymphocyte infusion; GvL, graft-versus-leukemia effect; LOC, loss of complete donor chimerism; MRD, measurable residual disease. Image created in BioRender.