TP53 mutations are prognostic in S0016 and specifically affect the prognosis on the RIT-CHOP arm but not on the R-CHOP arm. Of 147 patients, 72 showed disease progression and 44 died with a median of 15 years follow-up among those last known alive. (A,B) Mutations in TP53 were associated with shortened PFS in S0016 but not OS. (C,D) TP53 mutations affected PFS on RIT-CHOP arm but not on the R-CHOP arms (blue, no mutation detected; red, mutation detected).