Frequencies of TCE and expression alleles in data set 1 containing 356 188 phased exon 2-exon 3 sequences across 5 SIRE categories. The top half consists of a sunburst chart (left) showing expression-to-TCE allele frequencies for all sequences and grouped stacked bar charts (right) that stratify frequency information into individual SIREs. The bottom half shows the same information but in reverse: from TCE to expression. Concordant sequences are defined as having TCEs 1 and 2 with high HLA-DP expression or TCE 3 with low expression. The concordant groups are outlined in orange. Each sequence links to an immunogenic TCE group based on version 2 assignments of IPD-IMGT/HLA. Exon 3 SNPs (rs1126537, rs1126541, rs1042187, rs1042212, rs1042331, rs104335, and rs1071597) in each sequence infer HLA-DP expression levels.