A multicomponent analysis of data set 3 examining TCE-expression concordance rates, distributions of TCE-expression mismatches and expression-favorable alternatives, and median HLA-11/12 (HLA-A, -B, -C, -DRB1, and -DQB1-matched 10/10 + HLA-DPB1 single mismatch) donor search list sizes. The match category shorthand includes Ex– (expression-unfavorable), Ex+ (expression-favorable), TCE+ (TCE-permissive), and TCE– (TCE-nonpermissive). (A) Cross tabulation of patients’ immunogenic TCE and expression (mis)match categories and concordance and discordance rates between both models. Concordance rates are the proportion of concordant matches (green and red) within all expression-relevant matches (total of Ex+ and Ex–). NA indicates matches that were not applicable to the expression model (patients with homozygous high [H] or low [L] expression genotypes: HH or LL). (B) Distribution of HLA-DPB1 match types (based on expression and TCE) for 2545 donor-recipient transplantations in data set 3 conducted from 2008 to 2021 for 9.2% HH, 43.1% HL, and 47.6% LL expression genotype patients, who were also stratifed based on individual SIRE categories. The expression-relevant information is outlined in gold. (C) Median list sizes of 11/12 donor search lists across SIRE categories.